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Neurosurgeons are also obliged to adhere to medi-cal ethics principles

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Microdialysis study of cefotaxime cerebral distribu-tion in patients with acute brain injury. Testoste-rone is needed for normal spermatogenesis andmaturation of spermatozoa. Continuous infection istransferred from adjacent lymph nodes or infections from the surroundings. A selec-tion of frequently used epidemiologic metrics can be foundin Table 21.1. Many outcomes can be shown to be associated with an expo-sure, but the interpretation in a biological context is an important step.For example, a study could show that the risk of drowning in a population(the outcome) increases with increasing ice cream sales (the exposure), that is,that drowning and ice cream consumption are associated with each other.Technically, ice cream in this example is a risk factor, but it is unlikely to be acause of drowning. Another con?rmatory study showed that the effect onpatient survival of Mdm2/p53 cooverexpression was greater than the additive effectsof each independently [ 67]. After that time, Freudsuccumbed to the more comforting notion that these represented subjective fantasies on the partof patients

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As one example, it was shown that expression of the p53mutant, R273H, in A431 cells correlated with doxorubicin resistance and lowerrates of apoptosis [23]. Mechanisms of internalization of Staphylococcus aureus bycultured human osteoblasts. From a simplistic perspective, a phy-sician should always try to make EOL decisions and recommendations based onpurely clinical considerations, viewed in the context of the patient’s values. A critical review of the researchliterature helps inform clinical decision making. diet and lifestyle recommendations revision 2006: a scientific statement from theAmerican Heart Association nutrition Committee

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